2010 Fiscal Year Final Research Report
Cell biological analysis of GSCs/niche in medaka ovary
| Project/Area Number |
21770072
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Morphology/Structure
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| Research Institution | National Institute for Basic Biology |
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Principal Investigator |
NAKAMURA Shuhei National Institute for Basic Biology, 生殖遺伝学研究室, 特別協力研究員 (00510611)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 組織構築 / 幹細胞 / sox9 / GSCs / メダカ / 卵巣 |
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| Research Abstract |
There is no direct evidence that germline stem cells and their niche are present in the vertebrate adult ovary. We identified the testis cord-like network structure, termed 'ovarian cords', which is composed of sox9b-expressing cells and germ cells of early stage oogenesis in medaka ovary. In the ovarian cord, the regions in which germ cells are clustered are present (termed 'germinal cradle'). Clonal analysis using cre/loxP system revealed that germline stem cells supplying functional eggs exist in germinal cradle (Nakamura et al., Science, 2010). Our results provide insight into germline stem cell biology of medaka and provide a model system for studying vertebrate stem cell niches.
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[Journal Article] Transcriptional rewiring of the sex determining dmrt1 gene duplicate by transposable elements.2010
Author(s)
Herpin, A., Braasch, I., Kraeussling, M., Schmidt, C., Thoma, E.C., Nakamura, S., Tanaka, M., Schartl, M.
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Journal Title
PLoS Genet 6
Pages: e1000844
Peer Reviewed
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