2010 Fiscal Year Final Research Report
Molecular Mechanisms of RAD52-Mediated Homologous Recombination
| Project/Area Number |
21770127
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Structural biochemistry
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| Research Institution | Waseda University |
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Principal Investigator |
KAGAWA Wataru Waseda University, 理工学術院, 助教 (70415123)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 相同組換え / X線結晶構造解析 / 一本鎖DNA |
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| Research Abstract |
Homologous recombination is an important mechanism for genomic stability. To understand the underlying molecular mechanisms, three-dimensional structures of RAD52-single-stranded DNA complexes were solved by X-ray crystallography. The single-stranded DNA bound to RAD52 has a characteristic, right-handed helical structure, with bases exposed to the solvent. This structure appears suitable for the efficient search of homologous DNA sequences. The present structure provides the first clear view of how DNA homology search takes place.
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