2012 Fiscal Year Final Research Report
Analysis of themechanism for control the interaction between mitotic microtubules and dynamin.
| Project/Area Number |
21770143
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Functional biochemistry
|
|---|
| Research Institution | Hiroshima University |
|---|
Principal Investigator |
HAMAO Kozue 広島大学, 大学院・理学研究科, 准教授 (10403578)
|
|---|
| Project Period (FY) |
2009 – 2012
|
| Keywords | 細胞骨格 / 細胞分裂 / 微小管 / ダイナミン |
|---|
| Research Abstract |
To analyze the regulatory mechanisms for the dynamics of mitotic microtubules, I tried to elucidate the novel mechanisms for thebinding of dynamin to mitotic microtubules. I revealed that
(1) phosphorylation of dynamin by Cyclin B-cdc2 kinase reduces the binding ability of dynamin to micorotubules
(2) dynamin binds to SNX9 in interphasic cells
(3) the microtubule binding domain of dynamin is the proline-rich domain
(4) dynamin binds to dynamic microtubules
|
