2010 Fiscal Year Final Research Report
Single molecule observations of two heads coordination using hetero dimeric kinesin.
| Project/Area Number |
21770160
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biophysics
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| Research Institution | The University of Tokyo |
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Principal Investigator |
ARIGA Takayuki The University of Tokyo, 大学院・工学系研究科, 助教 (30452262)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 1分子計測 / 操作 |
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| Research Abstract |
We made various mutants combining kinesin 5 involved in centrosome separation during mitosis and kinesin 1 involved in vesicular transport, and observed their motility and conformations using single molecule techniques. The results elucidate that the motoric mode of kinesin 5 is switched by regulating the interactions between neck linker and motor head.
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