2010 Fiscal Year Final Research Report
Morphological plasticity and calcium dynamics in dendritic spines of neurons
| Project/Area Number |
21770161
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biophysics
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| Research Institution | The University of Tokyo |
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Principal Investigator |
WATANABE Satoshi The University of Tokyo, 大学院・医学系研究科, 助教 (80302610)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 脳・神経 / イメージング / ケージド化合物 / 二光子励起 |
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| Research Abstract |
In hippocampal pyramidal neurons, calcium elevation causes plasticity in synaptic transmission and spine morphology. I examined calcium dynamics during induction of plasticity with repeated uncaging of caged glutamate. During stimulation that induced spine enlargement, strong calcium elevation was evoked mainly by influx through NMDA receptors, and part of the calcium in the spine diffused out to the dendritic shaft.
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[Journal Article] In vivo two-photon uncaging of glutamate revealing the structure-function relationships of dendritic spines in the neocortex of adult mice.2011
Author(s)
Noguchi, J., Nagaoka, A., Watanabe, S., Ellis-Davies, G.C.R., Kitamura, K., Kano, M., Matsuzaki, M., Kasai, H.
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Journal Title
J.Physiol. 589
Pages: 2447-2457
Peer Reviewed
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[Journal Article] Learning rules and persistence of dendritic spines.2010
Author(s)
Kasai, H., Hayama, T., Ishikawa, M., Watanabe, S., Yagishita, S., Noguchi, J.
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Journal Title
Eur.J.Neurosci. 32
Pages: 241-249
Peer Reviewed
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[Presentation] 新しい2光子光刺激法の神経科学への応用2009
Author(s)
河西春郎, 金本悠矢, 松崎政紀, Graham Ellis-Davis, 百武篤也, 新井達郎, Klaus Hahn, Yi Wu, 石川資子, 野口潤, 葉山達也, 渡邊恵, 森田進
Organizer
第32回日本神経科学大会
Place of Presentation
名古屋国際会議場,名古屋市
Year and Date
2009-09-16
