2010 Fiscal Year Final Research Report
Functional analysis of PGC7/Stella as a DNA methylation regulator
| Project/Area Number |
21770207
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Cell biology
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| Research Institution | Osaka University |
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Principal Investigator |
NAKAMURA Toshinobu Osaka University, 大学院・医学系研究科, 助教 (80403202)
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| Project Period (FY) |
2009 – 2010
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| Keywords | クロマチン / PGC7 / DNAメチル化 / ヒストンメチル化 |
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| Research Abstract |
We found that PGC7 protects against active DNA demethylation via the binding to di-methylated histone H3 lysine9 in fertilized egg. In addition, we found that over expression of PGC7 induced DNA demethylation in somatic cells. Furthermore, we identified Np95, which is associated with maintenance of DNA methylation, as a binding partner of PGC7. Finally, we revealed that PGC7 inhibited the binding between Np95 and replication fork.
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