2011 Fiscal Year Final Research Report
Molecular mechanism of regulation of mitosis-specific chromosome dynamics
| Project/Area Number |
21770222
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Cell biology
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
KINOSHITA Kazuhisa 独立行政法人理化学研究所, 平野染色体ダイナミクス研究室, 専任研究員 (60447886)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 細胞周期 / 細胞分裂 / 染色体 / リン酸化 |
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| Research Abstract |
Condensin complexes play an essential role in regulation of mitotic chromosome dynamics. We developed an experimental system to express, purify and reconstitute recombinant condensin complexes in vitro. Finally, we have succeeded in reconstituting active, recombinant holo-complexes. Using the recombinant complexes, we elucidated the contributions of the ATPase cycle and the non-SMC subunits to condensin functions.
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