2010 Fiscal Year Final Research Report

Basic study for development of prion vaccines and immunotherapeutic methods using the newly immunogens

Research Project

Project/Area Number	21780277
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Applied veterinary science
Research Institution	Nagasaki University
Principal Investigator	YAMANAKA Hitoki Nagasaki University, 大学院・医歯薬学総合研究科, 助教 (30533921)
Project Period (FY)	2009 – 2010
Keywords	人獣共通感染症 / プリオン
Research Abstract	Prion diseases in humans and animals are fatal neurodegenerative disorders and no effective therapeutic methods for prion diseases were developed. In this study, to acquire the basic information for development of prion vaccine and immunotherapeutic methods, recombinant proteinase-sensitive (rPrP-sen) and -resistant prion protein (rPrP-res), were prepared by the real-time quaking-induced conversion method. The immunoresponses were evaluated by immunization to mice with these materials. The results from this study suggest that these materials, rPrP-sen and -res, are useful tools as a newly immunogen for development of prion vaccines and therapeutic methods.