2011 Fiscal Year Final Research Report
The role of HMGA1 for the G6Pase gene transcription
| Project/Area Number |
21780307
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Applied molecular and cellular biology
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| Research Institution | University of Tsukuba |
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Principal Investigator |
HIROTA Keiko 筑波大学, 生命環境系, 助教 (00375370)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 糖代謝 / 転写制御 / HMGA / インスリン / glucose-6-phosphatase / In vivo LUC / 線虫 / FOXO |
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| Research Abstract |
Gluconeogenesis, an extremely important metabolic pathway in the regulation of blood glucose levels under fasting conditions, is activated by glucagon and suppressed by insulin. The rate of gluconeogenesis is modulated by the levels of rate-limiting enzymes such as glucose-6-phosphatase (G6Pase). In this study, I analyzed the mechanism of the G6Pase gene expression and revealed that HMGA1 repressed the FOXO1-dependent G6Pase gene activation.
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Author(s)
Takahashi Y, Daitoku H, Hirota, K., Tamiya H, Yokoyama A, Kako K, Nagashima Y, Nakamura A, Watanabe S, Yamagata K, Yasuda K, Ishii N and Fukamizu A
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