2010 Fiscal Year Final Research Report
Studies on isolation, structure elucidation and asymmetric total syntheses of natural alkaloids towards the development of Alzheimer Disease
| Project/Area Number |
21790008
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Chemical pharmacy
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| Research Institution | Chiba University |
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Principal Investigator |
KOGURE Noriyuki Chiba University, 大学院・薬学研究院, 助教 (80396689)
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| Project Period (FY) |
2009 – 2010
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| Keywords | アルカロイド / 不斉全合成 / AChエステラーゼ / リコポジウム / ヒガンバナ |
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| Research Abstract |
In recent years, by the rapid increase of the elderly person, development of effective and safe drugs for memory improvement becomes the urgent business. The inhibition of acetylcholine esterase (AChE) brings increase of acetylcholine in the brain by controlling a function of and can improve defects of memory.
In this study, it was aimed for the search of alkaloids (base ingredient) which had AChE inhibitory activity by separation from Lycopodium and Amaryllidaceae plants, chemical synthesis of natural alkaloids. As a result, we succeeded in the isolation of many new alkaloids and achieved the total syntheses of several kinds of natural alkaloids.
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