2010 Fiscal Year Final Research Report
Development of a sensitive method for catecholamines using on-chip liquid chromatography
| Project/Area Number |
21790033
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Physical pharmacy
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| Research Institution | The University of Tokyo |
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Principal Investigator |
TSUNODA Makoto 東京大学, 大学院・薬学系研究科, 講師 (10323453)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 分析化学 |
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| Research Abstract |
The separation efficiency of a pillar array column under pressure-driven liquid chromatography conditions can be improved using a separation channel with low-dispersion turns. The pillar array column was fabricated by reactive ion etching of a silicon substrate. Two coumarin dyes were well resolved under reversed-phase conditions with a maximum theoretical plate number of 8000. Successful separation of the fluorescent derivatives of six amino acids was achieved in 140 s.
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