2010 Fiscal Year Final Research Report
Search for anti-diabetic constituents from medicinal foods-through the enhancement of glucose metabolism in hepatocytes-
| Project/Area Number |
21790122
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Drug development chemistry
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| Research Institution | Kinki University |
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Principal Investigator |
NINOMIYA Kiyofumi Kinki University, 薬学総合研究所, 助教 (10434862)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 生物活性物質 |
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| Research Abstract |
In order to investigate anti-diabetic constituents from medicinal foods, we examined following screening tests : (1) inhibitory effects on high glucose-induced triglyceride (TG) accumulation in HepG2 (2) effects on TG metabolism in high glucose pre-treated HepG2 (3) effects on glucose consumption in HepG2. As the results, acylated flavonol glycosides, tiliroside and helichrysoside, reduced TG contents in high glucose pre-treated HepG2 and enhanced glucose consumption in HepG2. In addition, administration of helicrysoside improved glucose tolerant in ddY mice. Furthermore, we found that isopteryxin, a khellactone-type coumarine, improved insulin-induced glucose consumption in HepG2 cells, and that neosedumoside II, a megastigmane glycoside, reduced TG contents in high glucose pre-treated HepG2.
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