2010 Fiscal Year Final Research Report
Development of a biomarker for assessing exposure to quinone compounds associated with producing reactive oxygen species
| Project/Area Number |
21790126
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Environmental pharmacy
|
|---|
| Research Institution | Kanazawa University |
|---|
Principal Investigator |
TORIBA Akira Kanazawa University, 薬学系, 准教授 (50313680)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
HAYAKAWA Kazuichi 金沢大学, 薬学系, 教授 (40115267)
KAMEDA Takayuki 金沢大学, 薬学系, 助教 (50398426)
TANG Ning 金沢大学, 薬学系, 助教 (90372490)
|
|---|
| Research Collaborator |
SIMPSON Christopher D. 米国・ワシントン大学, 准教授
|
|---|
| Project Period (FY) |
2009 – 2010
|
| Keywords | バイオマーカー / 酸化ストレス / 有害化学物質 / 大気汚染 / 曝露評価 |
|---|
| Research Abstract |
9,10-Phenanthrenequinone (PQ) has been suspected to be a causative factor in cardiovascular and allergic diseases which have been reported to be oxidative stress-related disorders. To develop a biological marker (biomarker) for assessing human exposure to PQ, an analytical method has been developed to determine urinary metabolites of PQ in human urine. For the first time, PQ metabolites in human urine were identified using the developed method.
|
