2010 Fiscal Year Final Research Report
High-throughput screening to identify novel factors for reprogramming
| Project/Area Number |
21790271
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
General medical chemistry
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| Research Institution | Kyoto University |
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Principal Investigator |
MAEKAWA Momoko Kyoto University, ウイルス研究所, 助教 (50528742)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 再生医学 |
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| Research Abstract |
Induced pluripotent stem cells (iPSC) are generated from somatic cells by the transgene expression of transcription factors containing protooncogenes. In this study, we screened natural product, chemical, and cDNA libraries for their ability to replace the protooncogenes. We identified novel factors for reprogramming and clarified reprogramming mechanism in part.
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