2010 Fiscal Year Final Research Report
Generation of conditional knockout of small Maf genes in mice
| Project/Area Number |
21790303
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Pathological medical chemistry
|
|---|
| Research Institution | Tohoku University |
|---|
Principal Investigator |
KATSUOKA Fumiki Tohoku University, 大学院・医学系研究科, 准教授 (30447255)
|
|---|
| Project Period (FY) |
2009 – 2010
|
| Keywords | 転写因子 / 疾患モデルマウス / 小Maf群因子 / 生体防御 |
|---|
| Research Abstract |
CNC-small Maf heterodimers are important for the regulation of various cytoprotective genes. This study revealed that small Maf proteins are indispensable for embryogenesis after E9.5, especially for liver development. This study also showed that the neurodegeneration observed in small Maf mutant mice is cell-autonomous effect. Conditional knockout system of small Maf proteins was established and will enable us to examine the function of small Maf proteins in adult tissues.
|
Research Products
(14 results)
-
[Journal Article] Central nervous system-specific deletion of transcription factor Nrf1 dcauses progressive motor neuronal dysfunction.2011
Author(s)
kira Kobayashi, Takako Tsukide, Tomohiro Miyasaka, Tomoko Morita, Tatsuya Mizoroki, Yoshiro Saito, Yasuo Ihara, Akihiko Takashima, Noriko Noguchi, Akiyoshi Fukamizu, Yosuke Hirotsu, Makiko Ohtsuji, Fumiki Katsuoka, Masayuki Yamamoto.
-
Journal Title
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
