2010 Fiscal Year Final Research Report
Analysis of the role of Rae1 on carcinogenesis and chromosome instability.
| Project/Area Number |
21790313
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Pathological medical chemistry
|
|---|
| Research Institution | Kanazawa University |
|---|
Principal Investigator |
WONG W・R Kanazawa University, フロンティアサイエンス機構, 特任准教授 (30464035)
|
|---|
| Project Period (FY) |
2009 – 2010
|
| Keywords | 核膜孔複合体 / Rae1 / RNA輸送 / 染色体不安定性 / 乳癌 / トランスジェニックマウス / 染色体異数化 / 多極紡錘体 |
|---|
| Research Abstract |
Abnormal expression of nuclear pore complex protein Rae1 makes aneuploidy and multi-polar spindles. It has been reported that Rae1 is one of the risk factors in breast cancer patients. In this study, we tried to analyze the relationship between Rae1 and breast cancer in vitro and in vivo. Therefore we successfully generated Rae1 transgenic mice in order to analysis of Rae1 expression in vivo. Moreover, we established Rae1 expression in insect cell Sf9 and purification it, which are useful for biochemical analysis.
|
-
[Journal Article] RNA export factor RAE1 contributes to NUP98-HOXA9-mediated leukemogenesis.2011
Author(s)
Funasaka T, Nakano H, Wu Y, Hashizume C, Gu L, Nakamura T, Wang W, Zhou P, Moore M, Sato H, Wong R
-
Journal Title
Cell Cycle.(co-1st author) 10
Pages: 1456-1467
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
