Investigation of allergic skin disease using mouse model

2010 Fiscal Year Final Research Report

• Project/Area Number: 21790335
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Pathological medical chemistry
• Research Institution: Tohoku University
• Principal Investigator: KAWANO Mitsuko Tohoku University, 加齢医学研究所, 教育研究支援者 (90422203)
• Project Period (FY): 2009 – 2010
• Keywords: 免疫学 / アレルギー

Research Abstract

Development of newly diagnosis and therapeutics are matter of great urgency, because prevalence of allergic skin disease is increasing explosively. In this research, molecular mechanisms of metal allergy, which is one of delayed-type hypersensitivity, were investigated using mouse model of metal allergy. As a result, specific T cell receptor (TCR) repertoire responsible to metal was identified and up-regulation of co-stimulatory molecule and cytokine was clarified. It is thought that this TCR repertoire and these molecules might be new marker and new therapeutic target of metal allergy, respectively.

Research Products

• [Journal Article] Hair growth regulation by the extract of aromatic plant Erica multiflora. (2009)
  • Author(s): Mitsuko Kawano., et al.
  • Journal Title: J.Nat.Med. 63 Pages: 335-339
  • Peer Reviewed
• [Presentation] Specific T cells increased by metal allergy. (2010)
  • Author(s): Mitsuko Kawano, et al.
  • Organizer: 第14回国際免疫学会議
  • Place of Presentation: 神戸国際会議場
  • Year and Date: 2010-08-26
• [Presentation] Increased specific T cells in the inflammation area of the metal allergy. (2009)
  • Author(s): Mitsuko Kawano, et al.
  • Organizer: 第39回日本免疫学会総会・学術集会
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 2009-12-03
• [Remarks]
  • URL: http://www.idac.tohoku.ac.jp/dep/imbio/