2012 Fiscal Year Final Research Report
Study for scoring system of human stem cells based on DNA methylation
| Project/Area Number |
21790372
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Human pathology
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| Research Institution | University of Miyazaki (2011-2012)
National Research Institute for Child Health and Development (2009-2010) |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2012
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| Keywords | ヒト幹細胞 / ヒトiPS細胞 / DNAメチル化 / 診断企画化 / 標準化 |
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| Research Abstract |
Human somatic stem cells and pluripotent stem cells including iPSCs are considered to be powerful resources in regenerative medicine. To define characters of human stem cells, we determined the DNA methylation profiles and compared among them. Continuous passaging of the iPSCs diminished the differences between iPSCs and ESCs, implying that iPSCs lose the characteristics inherited from the parent cells and adapt to very closely resemble ESCs over time.
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