2010 Fiscal Year Final Research Report
Candida infection and defense mechanism in APECED model mouse
Project/Area Number |
21790423
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Bacteriology (including Mycology)
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Research Institution | Kyushu University |
Principal Investigator |
KURISAKI Hironori Kyushu University, 医学研究院, 助教 (70403962)
|
Project Period (FY) |
2009 – 2010
|
Keywords | 感染免疫 / カンジダ感染 / APECED / Aire |
Research Abstract |
It was found that Aire KO and several immunodeficiency mice (μMT, Rag-1 and nu/nu) had a difference in susceptibility against Candida albicans infection by 3.0×105CFU intravenous challenge of the pathogen. In order to investigate the difference, we measured changes of IFN-γ, IL-4, IL-6 and IL-17A in C. albicans infection mice serum, because main cytokines of Th1, Th2 and Th17 response are IFN-γ,IL-4, IL-6 and IL-17A, respectively. We found that in Aire WT mice IFN-γ, IL-4 and IL-17A did not change, while the level of IL-6 only elevated. In Candida albicans infection, we supposed that innate immunity dependent on IL-6 production with the development of Th17 cells and a recruitment of phagocytes to induction of inflammation played an important role.
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