2011 Fiscal Year Final Research Report
Investigation of PE as a novel receptor for botulinum neurotoxin type D
| Project/Area Number |
21790430
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Bacteriology (including Mycology)
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| Research Institution | Fujita Health University |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Keywords | 病原性 / 細菌毒素 |
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| Research Abstract |
Botulinum neurotoxin type D possesses binding activity to phosphatidylethanolamine(PE), however, it is not unclear whether PE could mediate the internalization of the toxin into neuronal cells. In this study, we determined crystal structure of the receptor binding domain of the toxin. Moreover, we found that mouse embryonic carcinoma P19 cells exhibited high sensitivity to botulinum neurotoxin type C and D/C mosaic toxin, thus making them a novel susceptible cell line for research into botulinum neurotoxins.
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