2010 Fiscal Year Final Research Report
Role of MAP3Ks in the maintenance of mucosal immune homeostasis
Project/Area Number |
21790460
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Immunology
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Research Institution | The University of Tokyo |
Principal Investigator |
SATO Shintaro The University of Tokyo, 医科学研究所, 助教 (80447333)
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Project Period (FY) |
2009 – 2010
|
Keywords | 粘膜免疫 / 腸管上皮細胞 / MAP3K / 遺伝子改変マウス |
Research Abstract |
MAP3K family members act at upstream of MAPK such as JNK and p38. Among them, it has been reported that TAK1 and MEKK3 are also involved in the activation of NF-κB in response to several stimuli. We made conditional TAK1-deficient mice including intestinal epithelial cell-specific one (TAK1^<IEC-KO>), and reported the role of TAK1 in vivo. In this study, to elucidate the in vivo role of MEKK3 at IEC, we made and analyzed MEKK3^<IEC-KO> mice, and compared them with TAK1^<IEC-KO> mice. As a result, it was revealed that MEKK3, but not TAK1, was not involved in the activation of NF-κB in IEC. In addition, it was suggested that MEKK3 participated in maintenance of homeostasis of IEC.
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[Journal Article] Inflammatory Mediator TAK1 Regulates Hair Follicle Morphogenesis and Anagen Induction Shown by Using Keratinocyte-Specific TAK1-Deficient Mice.2010
Author(s)
Sayama K, Kajiya K, Sugawara K, Sato S, Hirakawa S, Shirakata Y, Hanakawa Y, Dai X, Ishimatsu-Tsuji Y, Metzger D, Chambon P, Akira S, Paus R, Kishimoto J, Hashimoto K.
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Journal Title
PLoS ONE. 5
Pages: e11275
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[Journal Article] Indigenous opportunistic bacteria inhabit mammalian gut-associated lymphoid tissues and share a mucosal antibody-mediated symbiosis.2010
Author(s)
Obata T, Goto Y, Kunisawa J, Sato S, Sakamoto M, Setoyama H, Matsuki T, Nonaka K, Shibata N, Gohda M, Kagiyama Y, Nochi T, Yuki Y, Fukuyama Y, Mukai A, Shinzaki S, Fujihashi K, Sasakawa C, Iijima H, Goto M, Umesaki Y, Benno Y, Kiyono H.
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Journal Title
Proc Natl Acad Sci USA. 107
Pages: 7419-7424
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[Journal Article] Intracellular Mycobacterium avium Intersect Transferrin in the Rab11(+) Recycling Endocytic Pathway and Avoid Lipocalin 2 Trafficking to the Lysosomal Pathway.2010
Author(s)
Halaas O, Steigedal M, Haug M, Awuh JA, Ryan L, Brech A, Sato S, Husebye H, Cangelosi GA, Akira S, Strong RK, Espevik T, Flo TH.
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Journal Title
J Infect Dis. 201
Pages: 783-792
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[Journal Article] Id2-, RORγt-, and LTβR-independent initiation of lymphoid organogenesis in ocular immunity.2009
Author(s)
Nagatake T, Fukuyama S, Kim DY, Goda K, Igarashi O, Sato S, Nochi T, Sagara H, Yokota Y, Jetten AM, Kaisho T, Akira S, Mimuro H, Sasakawa C, Fukui Y, Fujihashi K, Akiyama T, Inoue J, Penninger JM, Kunisawa J, Kiyono H.
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Journal Title
J Exp Med. 206
Pages: 2351-2364
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[Remarks] ホームページ等
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