2010 Fiscal Year Final Research Report
Monitoring and identification of type I IFN producing cells in vivo.
| Project/Area Number |
21790470
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Immunology
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| Research Institution | Osaka University |
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Principal Investigator |
KUMAGAI Yutaro Osaka University, 微生物病研究所, 特任助教 (00528408)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 自然免疫 / I型インターフェロン産生細胞 |
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| Research Abstract |
Type I IFN is important for innate immune response. However, cells producing type I IFN have not been fully identified yet. We generated a knock-in mouse strain where GFP is under control of Ifnb1 gene promoter. Observation of GFP expressing cells on viral or bacterial infection identified IFN-b-producing cells in vivo. IFN-b-producing cells in response to bacterial infection were different from that in viral infection. By crossing with various knock-out mouse strains for signaling molecules, we have identified signaling pathways essential for IFN-b production in response to bacteria in vivo.
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