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2010 Fiscal Year Final Research Report

Monitoring and identification of type I IFN producing cells in vivo.

Research Project

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Project/Area Number 21790470
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Immunology
Research InstitutionOsaka University

Principal Investigator

KUMAGAI Yutaro  Osaka University, 微生物病研究所, 特任助教 (00528408)

Project Period (FY) 2009 – 2010
Keywords自然免疫 / I型インターフェロン産生細胞
Research Abstract

Type I IFN is important for innate immune response. However, cells producing type I IFN have not been fully identified yet. We generated a knock-in mouse strain where GFP is under control of Ifnb1 gene promoter. Observation of GFP expressing cells on viral or bacterial infection identified IFN-b-producing cells in vivo. IFN-b-producing cells in response to bacterial infection were different from that in viral infection. By crossing with various knock-out mouse strains for signaling molecules, we have identified signaling pathways essential for IFN-b production in response to bacteria in vivo.

  • Research Products

    (4 results)

All 2011 2010 2009 Other

All Presentation (3 results) Remarks (1 results)

  • [Presentation] Identification and Characterization of in vivo IFN-b Producing Cells upon Bacterial Infection.2011

    • Author(s)
      Yutaro Kumagai, Shizuo Akira
    • Organizer
      Towards Comprehensive Understanding of Immune Dynamism 2011
    • Place of Presentation
      千里阪急ホテル(大阪)
    • Year and Date
      2011-03-01
  • [Presentation] Identification of in vivo IFN-b producing cells in response to bacterial infection.2010

    • Author(s)
      Yutaro Kumagai, Shizuo Akira
    • Organizer
      14th International Congress of Immunology
    • Place of Presentation
      神戸国際展示場(神戸)
    • Year and Date
      2010-08-25
  • [Presentation] Identification of in vivo IFN-b producing cells in response to bacterial infection.2009

    • Author(s)
      Yutaro Kumagai, Osamu Takeuchi, Shizuo Akira
    • Organizer
      第39回日本免疫学学術集会
    • Place of Presentation
      大阪国際会議場(大阪)
    • Year and Date
      2009-12-04
  • [Remarks] ホームページ等

    • URL

      http://hostdefense.ifrec.osaka-u.ac.jp/ja/index.html

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Published: 2012-02-13   Modified: 2016-04-21  

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