2010 Fiscal Year Final Research Report
Study on the molecular basis of the exertion of adverse effects of drugs mediated by regulation of NADPH oxidase activities
| Project/Area Number |
21790525
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Applied pharmacology
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
KATSUYAMA Masato Kyoto Prefectural University of Medicine, 医学研究科, 准教授 (60315934)
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| Project Period (FY) |
2009 – 2010
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| Keywords | NADPHオキシダーゼ / NOX / 活性酸素 / クリオキノール |
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| Research Abstract |
NOX is the catalytic subunit of NADPH oxidase, the superoxide-generating enzyme. Among several isoforms of NOX, NOX4 is abundantly expressed in various tissues. The mechanisms of constitutive and ubiquitous expression of NOX4 were clarified using SH-SY5Y and HEK293 cells. Sp3 transcription factor was found to play a key role in the expression of NOX4 in various cell lineages in human.
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Research Products
(2 results)
