2012 Fiscal Year Final Research Report
In silico study of mechanism and therapy of chronic atrial fibrillation based on the human atrial numerical model
| Project/Area Number |
21790717
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Shiga University of Medical Science |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2012
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| Keywords | 分子心臓病態学 / 不整脈学 |
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| Research Abstract |
We constructed the computer model of human atria, and conducted simulations (in silico) of chronic atrial fibrillation (AF). Then we found that fibroblast proliferation promotes AF chronicity and forms complex fractionated atrial electrogram (CFAE), known as the effective ablation target for chronic AF (Fibroblast-CFAE hypothesis). Our findings could contribute to better understanding of the mechanisms underlying CFAE-targeted AF ablation, and will improve the outcome of refractory chronic AF ablation.
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