2011 Fiscal Year Final Research Report
The role of IQGAP1 in heart failure prevention
| Project/Area Number |
21790743
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Kitasato University |
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Principal Investigator |
TOJO Minako (TOJO YAMAOKA Minako) 北里大学, 医療衛生学部, 准教授 (80327345)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 心不全 / 臓器保護 / 血管新生 / 予防医学 / 虚血再灌流 |
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| Research Abstract |
We investigated the role of IQ motif-containing GTPase-activating protein 1(IQGAP1), a scaffold protein for growth factor signaling and production of reactive oxygen species, on cardiac remodeling in response to ischemic heart damage using heart derived culture cells. IQGAP1 may be an important modulator for heart failure prevention, especially in extra matrix cell growth of the heart.
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[Presentation] The change of circulating interleukin-18 is associated with the change of arteriosclerosis, a 5-year observational study from Kitasato Registry of Cardiovascular Disease Prevention2011
Author(s)
Kameda R, Yamaoka-Tojo M, Wakaume K, Tojo T, Aiba N, Yoshida Y, Machida Y, Matsunaga A, Masuda T, Izumi T.
Organizer
The 75th Annual Scientific Meeting of the Japanese Circulation Society
Place of Presentation
Yokohama
Year and Date
20110000
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[Presentation] Association between Pentraxin 3 and renal function in patients at high risk of cardiovascular disease2011
Author(s)
Kameda R, Yamaoka-Tojo M, Tojo T, Wakaume K, Nemoto S, Kitasato L, Yoshida Y, Hatakeyama Y, Machida Y, Izumi T.
Organizer
The 15th Annual Scientific Meeting of Japanese Heart Failure Society
Place of Presentation
Kagoshima, Japan
Year and Date
2011-10-13
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[Presentation] Functional arterial stiffness predicts a thickening of carotid intima-media one year later in patients with lifestyle-related disease2011
Author(s)
Ogura NM, Kamekawa D, Kamiya K, Matsunaga A, Kimura M, Shimizu R, Ogura T, Noda C, Yamaoka-Tojo M, Masuda T.
Organizer
ESC 2011
Place of Presentation
Paris, France
Year and Date
2011-08-30
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[Presentation] Increased physical activity decreases circulating pentraxin 3 levels in patients at high risk of cardiovascular disease2011
Author(s)
Wakaume K, Yamaoka-Tojo M, Nemoto S, Kameda R, Aiba N, Tojo T, Yoshida Y, Machida Y, Masuda T, Izumi T.
Organizer
ESC 2011
Place of Presentation
Paris, France
Year and Date
2011-08-29
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[Presentation] The plasma levels of B-type natriuretic peptide is a useful predictor of cardiac events for out-clinic patients with asymptomatic heart failure who are in stable condition2011
Author(s)
Yamaoka-Tojo M, Kitasato L, Nemoto S, Wakaume K, Kameda R, Yoshida Y, Machida Y, Tojo T, Kasuda T, Izumi T.
Organizer
ESC 2011
Place of Presentation
Paris, France
Year and Date
2011-08-29
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[Presentation] Regular physical activity prevents atherosclerosis in high-risk patients with cardiovascular disease2011
Author(s)
Nemoto S, Yamaoka-Tojo M, Wakaume K, Yamamoto S, Kimura M, Ogura M, Aiba N, Kameda R, Machida Y, Yoshida Y, Matsunaga A, Masuda T, Izumi T.
Organizer
American College of Sports Medicine
Place of Presentation
Denver, CO, USA
Year and Date
2011-05-31
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[Presentation] Lifestyle modification-improving systemic athero-protective factor, circulating pentraxin 3, in high-risk patients with metabolic syndrome2010
Author(s)
Yamaoka-Tojo M, Tojo T, Wakaume K, Kameda R, Takahira N, Aoyama N, Matsunaga A, Masuda T, Izumi T.
Organizer
AHA2010
Place of Presentation
Chicago, IL, USA
Year and Date
2010-11-15
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[Presentation] Decreased strength of quadriceps increases the risk of mortality in patients with chronic heart failure2010
Author(s)
Kamiya K, Masuda T, Matsunaga A, Miida K, Ogura MN, Kimura M, Noda C, Yamaoka-Tojo M, Inomata T, Izumi T.
Organizer
AHA2010
Place of Presentation
Chicago, IL, USA
Year and Date
2010-11-15
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