2011 Fiscal Year Final Research Report
Control of bronchial asthma via Fc receptors on basophils
| Project/Area Number |
21790770
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Kobe University |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Keywords | 気管支喘息 / 好塩基球 / Fcレセプター |
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| Research Abstract |
In wild type mice, total cells and eosinophils in BAL fluid reduced after instillation with anti-OVA IgG1. Anti-OVA IgG1 suppressed airway inflammation in hyperresponsiveness and histology. These effects were lacking in Fc_YRIIB knockout mice. The deficit mice of basophils could not be sensitized allergic antigen and be taken a bronchial asthma. There were no significant difference in basophils activity derived from bone marrows of wild type mice and from that of Fc_YRIIB knockout mice.
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[Journal Article] The inhibitory effects of intravenous administration of rabbit immunoglobulin G on airway inflammation are dependent upon Fcγreceptor IIb on CD11c(+) dendritic cells in a murine model2010
Author(s)
Yamamoto M, Kobayashi K, Ishikawa Y, Nakata K, Funada Y, Kotani Y, Masuda A, Takai T, Azuma T, Yoshida M, Nishimura Y.
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Journal Title
Clin Exp Immunol
Volume: 162(2)
Pages: 315-24
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