2010 Fiscal Year Final Research Report
Investigation of the amyloid propagation in alpha-synucleinopathy
| Project/Area Number |
21790847
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Neurology
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
KASAI Takashi Kyoto Prefectural University of Medicine, 医学研究科, 助教 (70516062)
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| Project Period (FY) |
2009 – 2010
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| Keywords | α-シヌクレイン / オリゴマー / ニューロシン / パーキンソン病 |
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| Research Abstract |
We showed increased levels of extracelluar alpha-synuclein oligomer in CSF space of patients with Parkinson disease, which is supposed to play a role of amyloid propagation in alpha-synucleinopathy. We also demonstrated that Neurosin, a kind of serine proteases predominantly expressed in the central nervous system, secretes into extracelluar space and might play a role of extracelluar degradation of alpha-synuclein.
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[Journal Article] Elevated CSF TDP-43 levels in amyotrophic lateral sclerosis : specificity, sensitivity, and a possible prognostic value.2010
Author(s)
Noto Y, Shibuya K, Sato Y, Kanai K, Misawa S, Sawai S, Mori M, Uchiyama T, Isose S, Nasu S, Sekiguchi Y, Fujimaki Y, Kasai T, Tokuda T, Nakagawa M, Kuwabara S.
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Journal Title
Amyotroph Lateral Scler. 12
Pages: 140-143
Peer Reviewed
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