2010 Fiscal Year Final Research Report
Functional analysis of ZNF521 in hematopoietic cell differentiation
| Project/Area Number |
21790919
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Hematology
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| Research Institution | Ehime University |
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Principal Investigator |
YAMANOUCHI Jun Ehime University, 医学部附属病院, 講師 (10423451)
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| Project Period (FY) |
2009 – 2010
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| Keywords | ZNF521 / Evi3 / 赤血球 |
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| Research Abstract |
ZNF521(zinc finger protein 521) is a transcription factor with an N-terminal transcriptional repressor motif and 30 zinc finger domains. Although a high expression level of ZNF521 in human CD34+ progenitors and hematopoietic malignancies has been demonstrated, the functional role of ZNF521 in hematopoietic cell differentiation has not been clarified. In this study, we analyzed the role of ZNF521 in erythroid cell differentiation using the short hairpin RNA (shRNA)-mediated gene silencing method.
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