2010 Fiscal Year Final Research Report
Mechanism of oral tolerance controlled by a novel regulatory T cell subset associated with a T cell anergy inducing gene
| Project/Area Number |
21790940
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
膠原病・アレルギー・感染症内科学
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| Research Institution | The University of Tokyo |
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Principal Investigator |
OKAMURA Tomohisa The University of Tokyo, 医学部附属病院, 特任助教 (10528996)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 臨床免疫 / 制御性T細胞 |
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| Research Abstract |
Regulatory T cells(Tregs)are engaged in the maintenance of immunological self-tolerance. IL-10 has an important role in maintaining the normal immune state. However, it is difficult to assess the in vivo physiological function of IL-10-secreting Tregs because of the lack of its specific markers. Recently, we reported that IL-10-secreting Tregs can be delineated as CD4^+CD25^-Foxp3^-Tcells that characteristically express lymphocyte activation gene-3(LAG-3).Moreover, this novel CD4^+CD25^-LAG3^+Tregs(LAG3 Tregs)express anergy associated transcription factor Egr2, which confers Blimp-1, IL-10 and LAG3 expression of CD4^+Tcells. In this study, we confirmed the factors controlling LAG3 Treg-induction in an antigen specific manner. These findings could lead to the novel antigen-specific therapy for autoimmune diseases.
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Research Products
(12 results)
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[Journal Article] Regulatory polymorphisms in EGR2 are associated with susceptibility to systemic lupus erythematosus.2010
Author(s)
Myouzen K., Kochi Y., Shimane K., Fujio K., Okamura T., Okada Y., Suzuki A., Atsumi T., Ito S., Takada K., Mimori A., Ikegawa S., Yamada R., Nakamura Y., Yamamoto K.
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Journal Title
Hum.Mol.Genet. 19(11)
Pages: 2313-2320
Peer Reviewed
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