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2010 Fiscal Year Final Research Report

Analysis of cytokine production regulatory mechanism in basophils by immunoglobulin-like receptor PIR-B.

Research Project

  • PDF
Project/Area Number 21790945
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field 膠原病・アレルギー・感染症内科学
Research InstitutionTohoku Institute of Technology

Principal Investigator

SAKAMOTO Yuzuru  Tohoku Institute of Technology, 共通教育センター, 准教授 (30316434)

Project Period (FY) 2009 – 2010
Keywords好塩基球 / PIR-B / IL-3 / ITIM / Th2免疫応答
Research Abstract

To examine the potential involvement of PIR-B, the inhibitory type murine paired immunoglobulin-like receptor, in the regulation of Th2-type cytokine production in basophils, we used retroviral gene transfer system and analyzed PIR-B-deficient mice bone marrow-derived basophils. As a result, we found that PIR-B regulates IL-3-induced IL-4 production in murine basophils. Moreover, from the result of analysis that used various PIR-B mutants, PIR-B expressed on basophils negatively regulates IL-3-induced IL-4 production in an ITIM-independent manner, pointing to previously unrecognized regulatory mechanisms by PIR-B.

  • Research Products

    (8 results)

All 2010 2009 Other

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (7 results)

  • [Journal Article] Differential but competitive binding of Nogo and MHCI to PIR-B provides an inhibition of cells.

    • Author(s)
      Matsushita H, Endo S, Kobayashi E, Sakamoto Y, Kobayashi K, Kitaguchi K, Kuroki K, Soderhall A, Maenaka K, Nakamura A, Strittmatter SM, Takai T
    • Journal Title

      J Biol Chem (in press)

    • Peer Reviewed
  • [Presentation] Kinetic analysis of the association between PIR-B and its related molecules in B cells.2010

    • Author(s)
      Sakamoto Y, Watanabe Y, Nakamura A, Takai T
    • Organizer
      14^<th> International Congress of Immunology
    • Place of Presentation
      Kobe
    • Year and Date
      20100822-20100827
  • [Presentation] Paired immunoglobulin-like receptor (PIR)-B regulates IL-3-induced IL-4 production in a novel ITIM-independent manner in murine basophils.2010

    • Author(s)
      Oda A, Sakamoto Y, Koshi I, Takai T, Hida S, Taki S.
    • Organizer
      14^<th> International Congress of Immunology
    • Place of Presentation
      Kobe
    • Year and Date
      20100822-20100827
  • [Presentation] Regulation of cytotoxic T lymphocyte activity by CD8 and PIR-B.2010

    • Author(s)
      Endo S, Sakamoto Y, Kobayashi E, Nakamura A, Takai T
    • Organizer
      The 5th International Symposium of Institute Network
    • Place of Presentation
      Kanazawa
    • Year and Date
      20100624-20100625
  • [Presentation] 抑制型レセプターによる好塩基球のTh2免疫応答制御について2010

    • Author(s)
      坂本譲
    • Organizer
      JSEI-1^<st> Spring Seminar 2010
    • Place of Presentation
      宮城
    • Year and Date
      20100314-20100315
  • [Presentation] Competitive binding of MHC class I between PIR-B and CD8 regulates CTL activity.2009

    • Author(s)
      Endo S, Sakamoto Y, Nakamura A, Takai T
    • Organizer
      第39回日本免疫学会総会・学術集会記録第39巻, 128, 2009
    • Place of Presentation
      大阪
    • Year and Date
      20091202-20091204
  • [Presentation] Paired immunoglobulin-like receptor (PIR)-B attenuates IL-3-induced IL-4 production in a novel ITIM-independent manner in murine basophils.2009

    • Author(s)
      Sakamoto Y, Oda A, Hida S, Taki S
    • Organizer
      第39回日本免疫学会総会・学術集会記録第39巻, 95, 2009
    • Place of Presentation
      大阪
    • Year and Date
      20091202-20091204
  • [Presentation] Fc receptor γ-chain is a subunit of the IL-3 receptor, required for IL-4 production by murine basophils.2009

    • Author(s)
      Hida S, Sakamoto Y, Yamasaki S, Saito T, Taki S
    • Organizer
      9th World Congress on Inflammation
    • Place of Presentation
      Tokyo
    • Year and Date
      20090706-20090710

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Published: 2012-02-13   Modified: 2016-04-21  

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