2010 Fiscal Year Final Research Report
IL-17E signaling regulates podocyte function and proteinuria
| Project/Area Number |
21790998
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Pediatrics
|
|---|
| Research Institution | University of Miyazaki |
|---|
Principal Investigator |
KONOMOTO Takao University of Miyazaki, 医学部, 助教 (80315366)
|
|---|
| Project Period (FY) |
2009 – 2010
|
| Keywords | ポドサイト / インターロイキン17E / シグナル伝達 |
|---|
| Research Abstract |
IL-17E, a member of the IL-17 cytokine families, is known associate with allergic diseases. The roles of IL-17E are unknown in renal diseases. The aims of study are to investigate the effect of IL-17E on podocyte injuries. IL-17RB, a major receptor of IL-17E was expressed on human podocyte cell line. Our result showed that phosphorylation of ERK was increased and phosphorylation of p38MAPK transiently redused in the IL-17E treated podocyte. And the nephrin mRNA expression was up-regulated. Il-17E changed nephrin mRNA expression via ERK and p38MAPK signaling.
|
