2010 Fiscal Year Final Research Report
Studies on molecular mechanism of cyclosporine A to keratinocytes in psoriasis
| Project/Area Number |
21791071
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Dermatology
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| Research Institution | Nagoya University |
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Principal Investigator |
YOKOTA Kenji Nagoya University, 医学部附属病院, 助教 (20456651)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 小胞体ストレス応答 / ケラチノサイト / サイクロスポリンA / サイクロフィリンB / 尋常性乾癬 / ケラチノサイト増殖性疾患 / 小胞体ストレス / 有棘細胞癌 |
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| Research Abstract |
the UPR was downregulated in keratinocytes from psoriatic lesions, characterized by immunocytochemical staining of GRP78/Bip, CHOP/GADD153, HRD1 and C/EBPb. CyA treatment and siRNA-mediated knockdown of Cyp B induced the UPR in HaCaT cells or HSC-1 cells. Altogether, we demonstrate that in psoriasis vulgaris CyA or reduction in Cyp B by RNA interference might induce the UPR in keratinocytes.
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