The effect of atherosclerotic factors on mood disorder with treatment-resistance

2010 Fiscal Year Final Research Report

• Project/Area Number: 21791110
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Psychiatric science
• Research Institution: Gunma University
• Principal Investigator: NARITA Kosuke Gunma University, 大学院・医学系研究科, 助教 (70345677)
• Project Period (FY): 2009 – 2010
• Keywords: 双極性障害 / 治療抵抗性 / Voxel-Based Morphometry(VBM) / 動脈硬化 / インスリン抵抗性

Research Abstract

In this preliminary study with a cross-sectional design, we examined the regional gray matter (GM) volume in 14 bipolar II patients with RC, 17 patients without RC and 84 healthy controls by insulin-resistance index, calculated from blood glucose and insulin concentrations, and whole-brain and region-of-interest (ROI) analysis methods, using magnetic resonance imaging with voxel-based morphometry. Whole-brain analysis in this study revealed that the bipolar II patients with RC showed GM volume reductions in the bilateral hemispheres of the medial orbital prefrontal cortex, ventromedial prefrontal cortex, anterior cingulate, insula and parahippocampus, in the left hemisphere of the inferior temporal cortex and cerebellum, and in the brainstem, compared with the healthy controls. Moreover, ROI analysis focusing on the ventral prefrontal cortex, i.e., Brodmann areas 10, 11 and 47, revealed that the bipolar II patients with RC showed GM volume reduction in the ventromedial prefrontal cortex, compared with the patients without RC. The findings of our pilot study suggest that the ventromedial prefrontal cortex is associated with the generation of RC in bipolar II disorder. There were no significant results regarding insulin-resistance index.

Research Products

• [Journal Article] Volume reduction of ventromedial prefrontal cortex in bipolar II patients with rapid cycling : A voxel-based morphometric study. (2011)
  • Author(s): Narita K, Suda M, Takei Y, Aoyama Y, Majima T, Kameyama M, Kosaka H, Amanuma M, Fukuda M, Mikuni M
  • Journal Title: Prog Neuropsychopharmacol Biol Psychiatry. 35 Pages: 439-445
  • Peer Reviewed
• [Journal Article] Relationship of parental bonding styles with gray matter volume of dorsolateral prefrontal cortex in young adults. (2010)
  • Author(s): Narita K, Takei Y, Suda M, Aoyama Y, Uehara T, Kosaka H, Amanuma M, Fukuda M, Mikuni M
  • Journal Title: Prog Neuropsychopharmacol Biol Psychiatry. 34: Pages: 624-631
  • Peer Reviewed
• [Journal Article] Total and regional brain volume reductions due to the Syndrome of Irreversible Lithium-Effectuated Neurotoxicity (SILENT) : a voxel-based morphometric study. (2010)
  • Author(s): Ikeda Y, Kameyama M, Narita K, Takei Y, Suda M, Aoyama Y, Yuuki N, Sakurai N, Fukuda M, Mikuni M, Amanuma M
  • Journal Title: Prog Neuropsychopharmacol Biol Psychiatry. 34 Pages: 244-246
  • Peer Reviewed
• [Journal Article] Relationship between plasma leptin level and brain structure in elderly : a voxel-based morphometric study. (2009)
  • Author(s): Narita K, Kosaka H, Okazawa H, Murata T, Wada Y
  • Journal Title: Biol Psychiatry. 65 Pages: 992-994
  • Peer Reviewed