2010 Fiscal Year Final Research Report
Identification of suicidal-behavior related genes in the HPA axis regulating stress response
| Project/Area Number |
21791132
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Psychiatric science
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| Research Institution | Kobe University |
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Principal Investigator |
HISHIMOTO Akitoyo Kobe University, 大学院・医学研究科, 講師 (50529526)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 臨床精神分子遺伝学 |
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| Research Abstract |
We explored a positive association of suicidal behavior with certain haplotypes of FKBP5 gene which regulates the hypothalamo-pituitary-adrenal axis in stress response. We additionally explored associations of suicidal behavior with polymorphisms of ALDH2 and NOS1 genes. We also found a positive association of schizophrenia with polymorphisms of NOS1 gene. Our findings suggest that suicidal behavior is involved in the genetic vulnerability and that certain polymorphisms might be useful for a biomarker of suicidal behavior.
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Research Products
(24 results)
