2010 Fiscal Year Final Research Report
Stem cell therapy for fetal alcohol spectrum disorders
| Project/Area Number |
21791139
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Psychiatric science
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
YOSHINAGA Toshihiro Sapporo Medical University, 医学部, 助教 (70404704)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 脳・神経 / 神経科学 / 再生医学 / 神経幹細胞 / アルコール |
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| Research Abstract |
We presume that remodeling of neural network can be one of the strategies to treat fetal alcohol spectrum disorders (FASD). In this study, we suggest that transplantation of neural stem cells (NSC) to FASD model rats improve social and cognitive impairment of FASD. NSC transplanted via peripheral vein migrated into the brain of FASD model, and differentiated to various phenotypic neurons. These results suggest the possibility that NSC transplantation can be effective therapy for FASD.
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[Presentation] Stem cell therapy-social function recovery in FASD model2010
Author(s)
Shirasaka T, Ukai W, Hashimoto E, Ono T, Yoshinaga T, Ishii T, Tateno M, Watanabe K, Watanabe I, Kaneta H, Kigawa Y, Saito T
Organizer
International Society for Biomedical Research on Alcoholism
Place of Presentation
Paris, France.
Year and Date
20100913-20100916
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