2010 Fiscal Year Final Research Report
Role of polyunsaturated fatty acids in the development of schizophrenia
| Project/Area Number |
21791156
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Psychiatric science
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
MAEKAWA Motoko The Institute of Physical and Chemical Research, 分子精神科学研究チーム, 研究員 (50435731)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 統合失調症 / 多価不飽和脂肪酸 / オリゴデンドロサイト / GABA / 神経発達 / 環境因子 / ARMS |
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| Research Abstract |
In mice fed polyunsaturated fatty acids (PUFAs)-deficient diet during the brain developmental stage, we observed broad downregulation of genes related to oligodendrocyte and GABAergic systems, which is a current theory of functional psychoses. Moreover, we revealed that 1) mice raised with PUFAs-deficient diet showed poor volition detected by Y maze test, 2) neuronal activity of such mice was altered, which was examined by Mn-enhanced MRI. These results provide innovative clues for the pathophysiology of mental disorders, demonstrating an important role of PUFAs during neurodevelopement.
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Research Products
(16 results)
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[Journal Article] Excessive ingestion of long-chain polyunsaturated fatty acids during developmental stage causes strain- and sex-dependent eye abnormalities in mice.2010
Author(s)
Maekawa M, Iwayama Y, Watanabe A, Nozaki Y, Ohnishi T, Ohba H, Toyoshima M, Hamazaki K, Osumi N, Aruga J, Yoshikawa T.
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Journal Title
Biochem Biophys Res Commun. 402(2)
Pages: 431-437
Peer Reviewed
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[Journal Article] Arachidonic acid drives postnatal neurogenesis and elicits a beneficial effect on prepulse inhibition, a biological trait of psychiatric illnesses.2010
Author(s)
Maekawa M, Takashima N, Matsumata M, Ikegami S, Kontani M, Hara Y, Kawashima H, Owada Y, Kiso Y, Yoshikawa T, Inokuchi K, Osumi N.
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Journal Title
Brain Pathol. 20(6)
Pages: 1033-1041
Peer Reviewed
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[Journal Article] Failure to confirm genetic association of the FXYD6 gene with schizophrenia: the Japanese population and meta-analysis.2010
Author(s)
Iwata Y, Yamada K, Iwayama Y, Anitha A, Thanseem I, Toyota T, Hattori E, Ohnishi T, Maekawa M, Nakamura K, Suzuki K, Matsuzaki H, Tsuchiya KJ, Suda S, Sugihara G, Takebayashi K, Yamamoto S, Iwata K, Mori N, Yoshikawa T.
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Journal Title
Am J Med Genet B Neuropsychiatr Genet. 153B(6)
Pages: 1221-1227
Peer Reviewed
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[Journal Article] Association analyses between brain-expressed fatty-acid binding protein (FABP) genes and schizophrenia and bipolar disorder.2010
Author(s)
Iwayama Y, Hattori E, Maekawa M, Yamada K, Toyota T, Ohnishi T, Iwata Y, Tsuchiya KJ, Sugihara G, Kikuchi M, Hashimoto K, Iyo M, Inada T, Kunugi H, Ozaki N, Iwata N, Nanko S, Iwamoto K, Okazaki Y, Kato T, Yoshikawa T.
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Journal Title
Am J Med Genet B Neuropsychiatr Genet. 153B(2)
Pages: 484-493
Peer Reviewed
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[Journal Article] Polymorphism screening of brain-expressed FABP7, 5 and 3 genes and association studies in autism and schizophrenia in Japanese subjects.2010
Author(s)
Maekawa M, Iwayama Y, Arai R, Nakamura K, Ohnishi T, Toyota T, Tsujii M, Okazaki Y, Osumi N, Owada Y, Mori N, Yoshikawa T.
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Journal Title
J Hum Genet. 55(2)
Pages: 127-130
Peer Reviewed
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[Journal Article] A novel missense mutation (Leu46Val) of PAX6 found in an autistic patient.2009
Author(s)
Maekawa M, Iwayama Y, Nakamura K, Sato M, Toyota T, Ohnishi T, Yamada K, Miyachi T, Tsujii M, Hattori E, Maekawa N, Osumi N, Mori N, Yoshikawa T.
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Journal Title
Neurosci Lett. 462(3)
Pages: 267-271
Peer Reviewed
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