Development of Computer-aided Classification System for early-onset Alzheimer' s Disease based on Three-dimensional Functional Magnetic Resonance Imaging

2011 Fiscal Year Final Research Report

• Project/Area Number: 21791199
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Radiation science
• Research Institution: Kyushu University
• Principal Investigator: YAMASHITA Yasuo 九州大学, 大学病院, その他 (70380516)
• Project Period (FY): 2009 – 2011
• Keywords: 医用画像工学 / コンピュータ支援診断学

Research Abstract

In recent years, various sorts of computer-aided diagnosis(CAD) system for Alzheimer' s disease(AD) patients have been developed to evaluate the degree of the atrophy in the cerebral cortex using morphological features in MR images. In this study, we developed a CAD system for AD patients based on functional imaging features derived from the cerebral blood flow maps measured by arterial spin labeling(ASL) technique which is one of magnetic resonance imaging(MRI) techniques. Our preliminary results suggest that the proposed method based on functional imaging features obtained by the ASL technique would be feasible for detection of patients with AD and would be expected using for a screening examination and a follow-up examination under treatment of AD.

Research Products

• [Journal Article] MR脳血流マップ画像を用いたアルツハイマー病の鑑別支援システムの開発 (2011)
  • Author(s): 山下泰生, 有村秀孝, 吉浦敬, 徳永千晶, 桑水流純平, 馬込大貴, 門司晃, 小林幸次, 古閑省一, 中村泰彦, 大屋信義, 本田浩, 大喜雅文, 豊福不可依
  • Journal Title: 医用画像情報学会雑誌 Volume: Vol.28, No.3 Pages: 72-78
  • Peer Reviewed
• [Presentation] Features of Arterial Spin Labeling Cerebral Blood Flow (2011)
  • Author(s): Yamashita Y
  • Organizer: Radiological Society of North America 2011(RSNA)
  • Place of Presentation: CHICAGO, IL
  • Year and Date: 2011-12-01
• [Presentation] ASLの脳血流マップを用いたアルツハイマー型認知症の鑑別支援診断システムの開発 (2011)
  • Author(s): 山下泰生
  • Organizer: 医用画像情報学会
  • Place of Presentation: 徳島
  • Year and Date: 2011-10-22
• [Presentation] Computerized Classification of Patients with Alzheimer' s Disease Based on Arterial Spin-Labeled perfusion MRI (2010)
  • Author(s): Yamashita Y
  • Organizer: World Automation Congress2010
  • Place of Presentation: Kobe, Japan
  • Year and Date: 2010-09-20
• [Presentation] Computer-aided Classification of Patients with Alzheimer' s Disease Based on Cerebral Blood Flow Map measured by Arterial Spin Labeling MRI (2010)
  • Author(s): Yamashita Y
  • Organizer: MRI, Computer Assisted Radiology and Surgery
  • Place of Presentation: Geneva
  • Year and Date: 2010-06-23
• [Presentation] Computer-aided classification of patients with dementia of Alzheimer' s type based on cerebral blood flow determined with arterial spin labeling technique (2010)
  • Author(s): Yamashita Y
  • Organizer: SPIE International Symposium Medical Imaging
  • Place of Presentation: San Diego, FL
  • Year and Date: 2010-02-18