2010 Fiscal Year Final Research Report
Elucidation of pathway and molecular mechanism of radiation-induced non-apoptotic cell death mode in human solid carcinoma cell
| Project/Area Number |
21791201
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Radiation science
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| Research Institution | Nagasaki University |
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Principal Investigator |
SUZUKI Masatoshi Nagasaki University, 医歯薬学総合研究科, 研究員 (60515823)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 放射線 / 細胞死 / 老化様増殖停止 / 生細胞イメージング |
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| Research Abstract |
Live-cell imaging of mammary carcinoma cell line revealed prolonged cell cycle arrest as a predominant cell death mode induced by ionizing radiation. Regardless cell cycle phase that exposed to ionizing radiation, prolonged cell cycle arrest was induced in G1 phase. Particularly, direct cell cycle progression from G2 to G1 phase without mitosis was observed by G2-irradiation in presence of p53, suggesting that radiochemotherapy combined with taxane-treatment increases the treatment-sensitivity for p53-depleted carcinoma cells.
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