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2011 Fiscal Year Final Research Report

Cryoablation for lung tumors : optimal freeze-thaw sequence and clinical application

Research Project

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Project/Area Number 21791214
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Radiation science
Research InstitutionKeio University

Principal Investigator

INOUE Masanori  慶應義塾大学, 医学部, 助教 (30338157)

Project Period (FY) 2009 – 2011
Keywordsインターベンショナルラジオロジー(IVR)
Research Abstract

1) We drew the isothermal curves by measuring the temperature of a normal porcine lung in vivo based on the same freeze-thaw cycles as actual cryoablation for malignant lung tumors. As a result of the analysis with the isothermal curve and the freezing function, the frozen area of the iceball was larger in the second cycle than in the first cycle. It is supposed that bleeding in the first freeze-thaw cycle increases the thermal diffusivity around the cryoprobe and it is enabled to freeze a greater area in the second freezing. 2) The correlation between the isothermal curves and histologic findings was examined. These findings were also compared with the clinical findings on computed tomography(CT). The present study has demonstrated that the less than-20℃zone corresponds to the central solid zone on CT.

  • Research Products

    (7 results)

All 2012 2011 2010 2009

All Journal Article (5 results) (of which Peer Reviewed: 5 results) Presentation (2 results)

  • [Journal Article] Prediction of the critical thermal zone during pulmonary cryoablation on computed tomography from correlated experimental and clinical findings2012

    • Author(s)
      Hashimoto K, Izumi Y, Yamauchi Y, Yashiro H, Inoue M, et al
    • Journal Title

      J Thorac Cardiovasc Surg

      Volume: 13

    • Peer Reviewed
  • [Journal Article] Percutaneous cryoablation of lung tumors : feasibility and safety2012

    • Author(s)
      Inoue M, Nakatuska S, Yasho H, et al
    • Journal Title

      J Vasc Interv Radiol

      Volume: 23(3) Pages: 303-5

    • Peer Reviewed
  • [Journal Article] Percutaneous Cryoablation for the Treatment of Medically Inoperable Stage I Non-Small Cell Lung Cancer2012

    • Author(s)
      Yamauchi Y, Izumi Y, Hashimoto K, Yashiro H, Inoue M, et al
    • Journal Title

      PLoS One

      Volume: 7(3) Pages: e33223

    • Peer Reviewed
  • [Journal Article] Percutaneous cryoablation of pulmonary metastases from colorectal cancer2011

    • Author(s)
      Yamauchi Y, Izumi Y, Kawamura M, Nakatsuka S, Yashiro H, Tsukada N, Inoue M, et al
    • Journal Title

      PLoS One

      Volume: 6(11) Pages: e27086

    • Peer Reviewed
  • [Journal Article] On freeze-thaw sequence of vital organ of assuming the cryoablation for malignant lung tumors by using cryoprobe as heat source2010

    • Author(s)
      Nakatsuka S, Yashiro H, Inoue M, et al
    • Journal Title

      Cryobiology

      Volume: 61(3) Pages: 317-26

    • Peer Reviewed
  • [Presentation] Does "vessel guard(VG) technique" improve local control rate in cryoablation for lung tumors?2011

    • Author(s)
      M. Inoue, S. Nakatsuka, H. Yashiro, et al
    • Organizer
      CIRSE(Cardiovascular and Interventional Radiological Society of Europe)
    • Place of Presentation
      Munich, Germany
    • Year and Date
      20110910-14
  • [Presentation] Thawing until temperature reaches a plateau is required for maximum frozen volume in lung cryoablation2009

    • Author(s)
      M. Inoue, S. Nakatsuka, H. Yashiro, et al
    • Organizer
      CIRSE(Cardiovascular and Interventional Radiological Society of Europe)
    • Place of Presentation
      Lisbon, Portugal
    • Year and Date
      20090919-23

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Published: 2013-07-31  

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