2011 Fiscal Year Final Research Report
The relationship between serum cytokine and unstable plaque detected by PET/CT and coronary CT
| Project/Area Number |
21791225
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Radiation science
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| Research Institution | Kurume University |
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Principal Investigator |
KAIDA Hayato 久留米大学, 医学部, 助教 (40299425)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 核医学(PETを含む) |
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| Research Abstract |
The aim of this study were to investigate the relationship between FDG uptake in carotid unstable plaque and coronary unstable plaque detected by coronary CT, and to correlate FDG uptake in carotid unstable plaque with serum cytokine(MPO, PTX, ADMA, hs CRP and MDA-LDL). Target-to-background ratio(TBR) was used for evaluating the FDG uptake in carotid plaque. TBR correlated with hs CRP and MDA LDL significantly. Especially, TBR correlated with MDA-LDL better than hsCRP. Three of 80 patients underwent coronary CT because there were abnormal findings on load electrocardiogram. Only one of 3 patients had 50% coronary stenosis and coronary unstable plaque, and another two patients did not. As a result, the relationship between FDG uptake in carotid plaque and coronary unstable plaque was not cleared.
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