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2011 Fiscal Year Final Research Report

Development of the novel molecular targeted therapy against hepatocellular carcinoma invasion and metastasis

Research Project

  • PDF
Project/Area Number 21791288
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Digestive surgery
Research InstitutionHiroshima University

Principal Investigator

KOBAYASHI Tsuyoshi  広島大学, 病院, 病院助教 (50528007)

Project Period (FY) 2009 – 2011
Keywords癌 / 遺伝子 / 蛋白質 / 細胞・組織 / 外科
Research Abstract

The aim of this study was to develop the novel molecular targeted therapy against hepatocellular carcinoma invasion and metastasis. Although we were not able to clarify the clinical significance of expression of h-prune in hepatocellular carcinoma, we elucidated that h-prune frequently expressed in thyroid cancers and had an essential role in anaplastic thyroid cancer cell invasion and metastasis.

  • Research Products

    (9 results)

All 2012 2011 Other

All Journal Article (5 results) (of which Peer Reviewed: 3 results) Presentation (3 results) Remarks (1 results)

  • [Journal Article] No impact of perioperative blood transfusion on recurrence of hepatocellular carcinoma after hepatectomy2012

    • Author(s)
      Kuroda S, Tashiro H, Kobayashi T, et al
    • Journal Title

      World journal of surgery

      Volume: 36 Pages: 651-8

    • Peer Reviewed
  • [Journal Article] 甲状腺未分化癌の浸潤転移機構におけるh-pruneの役割2011

    • Author(s)
      楠部潤子, 小林剛, 田代裕尊, 他
    • Journal Title

      内分泌外科

      Volume: 28 Pages: 232-237

  • [Journal Article] Selection criteria for hepatectomy in patients with hepatocellular carcinoma classified as Child-Pugh class B2011

    • Author(s)
      Kuroda S, Tashiro H, Kobayashi T, et al
    • Journal Title

      World J Surg

      Volume: 35 Pages: 834-41

    • Peer Reviewed
  • [Journal Article] Tumor-related factors do not influence the prognosis of solitary hepatocellular carcinoma after partial hepatectomy2011

    • Author(s)
      Kobayashi T, Itamoto T, Tashiro H, et al.
    • Journal Title

      J Hepatobiliary Pancreat Sci

      Volume: 18 Pages: 689-99

    • DOI

      DOI:10.1007/s00534-011-0379-4

    • Peer Reviewed
  • [Journal Article] 肝癌再発予防2011

    • Author(s)
      小林剛, 大段秀樹.
    • Journal Title

      外科治療

      Volume: 105 Pages: 467-474

  • [Presentation] 世界に発信する内分泌外科の臨床と基礎研究甲状腺未分化癌の浸潤転移機構におけるh-pruneの役割2011

    • Author(s)
      楠部潤子, 小林剛, 田代裕尊, 杉野圭三, 嶋本文雄, 大段秀樹
    • Organizer
      日本内分泌外科学会総会
    • Place of Presentation
      東京
    • Year and Date
      20110600
  • [Presentation] 甲状腺未分化癌の浸潤転移機構におけるh-pruneの役割2011

    • Author(s)
      楠部潤子, 小林剛, 田代裕尊, 杉野圭三, 嶋本文雄, 菊池章, 大段秀樹
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-10-03
  • [Presentation] 高度脈管侵襲を伴う肝細胞癌に対する肝切除成績2011

    • Author(s)
      小林剛、田代裕尊, 天野尋暢, 大下彰彦, 谷本新学, 田澤宏文, 黒田慎太郎, 楠部潤子, 藤國宣明, 相方浩, 大段秀樹.
    • Organizer
      第23回日本肝胆膵外科学会・学術集会
    • Place of Presentation
      東京
    • Year and Date
      2011-06-10
  • [Remarks]

    • URL

      http://home.hiroshima-u.ac.jp/home2ge/research_liver.html

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Published: 2013-07-31  

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