2010 Fiscal Year Final Research Report

Protective effect of antimicrobial peptides based on the beetle defensins on Artificial blood vessel infection

Research Project

Project/Area Number	21791318
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Thoracic surgery
Research Institution	Gifu University
Principal Investigator	NACHI Sho Gifu University, 医学部附属病院, 医員 (30452155)
Project Period (FY)	2009 – 2010
Keywords	外科 / 感染制御 / 抗菌ペプチド
Research Abstract	The Cecal ligation and puncture (CLP) model is a clinical septicemic and infection model. We gave antimicrobial peptide and examined effect of treatment on CLP model. Control group was CLP control group. Peptide group was injected intraperitoneally with antimicrobial peptides before closing the abdomen. In the peptide group, the survival days were significantly prolonged as compared with control group. IL-6 and TNF-α and endotoxin levels were low level in the peptide group than the control group. Thus, not only we significantly prolonged the survival days by the administration to CLP model, but also the antimicrobial peptide controlled inflammatory reaction, and there was thought to be effect of treatment.