2010 Fiscal Year Final Research Report

GALNT3 functions in phosphate homeostasis and bone biology

Research Project

Project/Area Number	21791404
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Orthopaedic surgery
Research Institution	Nagasaki University
Principal Investigator	YOSHIDA CarolinaAndrea Nagasaki University, 大学院・医歯薬総合研究科, 助教 (50437828)
Project Period (FY)	2009 – 2010
Keywords	Galnt3 / 骨 / リン代謝
Research Abstract	Loss of function mutations in the GALNT3 gene result in under-glycosylation and subsequent proteolysis of FGF23, leading to hype rostosis-hype rphosphatemi a syndrome or tumoral calcinosis. Using Galnt3 null (^<-/->) mice, we corroborated the roles of GALNT3 in the maintenance of active FGF23, thus in Pi homeostasis and we analyzed its functions in bone and testis biology. We found that Galnt3' mice had increased bone volume and a trabecular bone with cartilage inclusions, despite the facts that osteoblast differentiation and osteoclast activity were normal. GALNT3 is also important for sperm production and maturation, as evidenced by the apoptosis seen in the epydimis of the Galnt3^<-/-> mice.

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