2011 Fiscal Year Final Research Report
The development and analyses of the mouse model of age-related osteoporosis.
| Project/Area Number |
21791416
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Juntendo University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NOJIRI Hidetoshi 順天堂大学, 医学部, 助教 (10317456)
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| Co-Investigator(Renkei-kenkyūsha) |
SHIMIZU Takahiko 千葉大学, 大学院・医学研究科, 准教授 (40301791)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 老化 / 骨粗鬆症 / 酸化ストレス / スーパーオキサイドディスムターゼ(SOD) |
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| Research Abstract |
We revealed that the relationships between oxidative stress and age-related osteoporosis by analyzing the bone tissue of superoxide dismutase 1(SOD1). deficient mouse. This mouse showed low turnover bone remodeling osteoporosis similar to that of age-related osteoporosis and that was rescued by oral administration of vitamin C. These results may help us to know the unknown mechanisms and establishment of the treatment strategy for age-related osteoporosis.
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