2010 Fiscal Year Final Research Report
The effect of tumor secreting physiologically active substances for synaptic transmission.
| Project/Area Number |
21791458
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | University of Miyazaki |
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Principal Investigator |
KASHIWADA Masatoshi University of Miyazaki, 医学部, 助教 (20336316)
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| Project Period (FY) |
2009 – 2010
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| Keywords | リドカイン / アポトーシス / 腫瘍特異性 |
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| Research Abstract |
Many studies have indicated that the expression of for NaV1.3 a kind of voltage-dependent sodium channels by tumor secreting physiologically active substances is one of the mechanisms of cancer pain. The aim of this study was to invest the effect of tumor secreting physiologically active substances for expression of voltage-dependent sodium channels by using Rat dorsal root ganglion (DRG) neurons. Results : NaV 1.3 was most expressed by NGF and TNF-α. Conclusion : NaV1.3 expression by tumor secreting physiologically active substances such as NGF and TNF-α may be one of the causes of cancer pain.
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