2010 Fiscal Year Final Research Report
Gene-expression analysis of AR-negative prostate cancer cells
| Project/Area Number |
21791508
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Urology
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| Research Institution | Kochi University |
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Principal Investigator |
TAMURA Kenji Kochi University, 教育研究部医療学系, 助教 (50464384)
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| Project Period (FY) |
2009 – 2010
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| Keywords | マイクロアレイ / ゲノム / トランスレーショナルリサーチ / 癌 / 発現制御 |
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| Research Abstract |
To identify prostate cancer (PC) specific biomarkers, which are independent of PSA, we analyzed gene expression profiles of PC cell lines (PC-3, DU145, 22Rv1 and LNCaP) by genome-wide cDNA microarray and found dozens of trans-activated genes in AR-negative PC cell lines (PC-3 and DU145), compared with AR-positive PC cell lines (22Rv1 and LNCaP). Among them, we identified a new biomarker, KURO3, as an overexpressed gene in PC-3 cell line and clinical high-grade prostate cancers.
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