2011 Fiscal Year Final Research Report

Roles of intrinsic angiogenesis inhibitor, vasohibin, in cervical carcinomas.

Research Project

Project/Area Number	21791538
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Obstetrics and gynecology
Research Institution	Tohoku University
Principal Investigator	YOSHINAGA Kousuke 東北大学, 病院, 准教授 (40343058)
Project Period (FY)	2009 – 2011
Keywords	子宮頚癌 / 血管新生 / vasohibin / VEGF
Research Abstract	The aim of the present study is to clarify the critical roles of vasohibin in cervical carcinomas. We investigated the expression ratios of vasohibin and vascular endothelial growth factor (VEGF)receptor-2 on endothelium and microvessel density, lymphatic vessel density (LVD)by immunohistochemistry. Sixty-one squamous cell carcinoma (SCC), 18 mucinous adenocarcinoma (Adenocarcinoma), 38 carcinoma in situ (CIS), and 35 normal cervical epithelium were collected. This is the first study to elucidate the correlation between the expression of vasohibin in the stromal endothelial cells and the expression of VEGFR-2 in human cervical carcinomas.