2010 Fiscal Year Final Research Report
Elucidation of a gene-specific regulatory mechanism with progesterone in the human endometrial stromal cells
| Project/Area Number |
21791559
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Yamaguchi University |
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Principal Investigator |
TAKETANI Toshiaki Yamaguchi University, 医学部附属病院, 助教 (70464328)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 生殖医学 |
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| Research Abstract |
ChIP assay revealed that TNFα increased NF-κB binding at both the COX-2 promoter and the Mn-SOD promoter, and that progesterone only inhibited the NF-κB binding at the COX-2 promoter. The histone acetylation level of the NF-κB response element of the Mn-SOD promoter was lower than that of the COX-2 promoter. The gene-specific action of progesterone may be due to the difference in chromatin structure at the NF-κB response elements in the COX-2 promoter and Mn-SOD promoter.
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