2010 Fiscal Year Final Research Report
Analysis of a new molecule target action of topotecan using a promoter microarray
| Project/Area Number |
21791578
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Osaka Medical College |
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Principal Investigator |
SASAKI Hiroshi Osaka Medical College, 医学部, 助教 (80432491)
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| Project Period (FY) |
2009 – 2010
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| Keywords | シスプラチン / トポテカン / プラチナ耐性 / Akt / NF・B / VEGF / 卵巣癌 |
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| Research Abstract |
We revealed the mechanism that Topotecan reacquire the effect of cisplatin in platinum resistance ovarian cancer. Furthermore we revealed the mechanism of angiogenesis by cisplatin in platinum resistance ovarian cancer.
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