2010 Fiscal Year Final Research Report
Mechanism of invasion and metastasis of thyroid papillary carcinoma with minute ossification
| Project/Area Number |
21791641
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Kitasato University |
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Principal Investigator |
TAKEDA Masahiko Kitasato University, 医学部, 助教 (50327417)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 甲状腺 / 乳頭癌 / 骨化 / basic fibroblast growth factor / bone morphogenic protein |
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| Research Abstract |
High potential of invasion and lymph node metastasis of thyroid papillary carcinoma with minute ossification was shown. The neo-ossification was related with expression of bFGF and BMP-2. In addition, induction of neo-vascularization initiated by high expression of VEGF may resulted in vascular invasion of cancer cells.
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